■ 病理診断
気管支鏡生検
99mTc-MAA
肺血流シンチ

■ 確定診断名 Adenoid cystic carcinoma:腺様嚢胞癌

■ 考 察 ◆肺血流シンチで一側性の集積欠損(perfusion defect)を認める疾患
  • 縦隔・肺門部腫瘍・・・気管支腫瘍、気管支異物、リンパ節転移
  • 肺血栓・塞栓症
  • 大動脈解離
  • 胸膜炎
  • 肺実質病変・・・肺気腫、放射線治療後
  • 炎症後の反応・・・Swyer-James-Syndrome
  • 先天性肺動脈奇形
  • 肺、心疾患の手術後、不適切なスワンガンツカテーテル留置

◆気管支の通過障害でperfusion defectを生じる理由

  • その原因は諸説あるが・・・
    ・呼気時に腫瘍・異物がチェックバルブとして働き、air trappingすることで肺胞内圧が上昇し局所血流が低下する
    ・換気不全により反応性に低酸素性の肺血管収縮を引き起こす
  • 本症例では肺野の透過性亢進に加え,呼気時の連続性ラ音を聴取しており、air trappingによるperfusion defectと考えられる

■参考文献
  1. Tapan K. Chaudhuri, Tuhin K. et al. Abnormal Lung Perfusion in a Patient with Bronchial Adenoma Chest 1972;62;110-112
  2. Alessandro Giordano, Maria Lucia Calcagni, Guido Meduri,et al. Perfusion Lung Scintigraphy for the Prediction of Postlobectomy Residual Pulmonary Function. Chest 1997;111;1542-1547
  3. H E Ward, R L Jones, E G King,et al.Reversible ventilation and perfusion abnormalities in unilateral obstructed lung. Chest 1982;81;11-15
  4. J C Giudice, R Gordon and H J Komansky. Endobronchial lipoma causing unilateral absence of pulmonary perfusion. Chest 1980;77;104-105
  5. White RI Jr, James AE Jr, Wagner HN Jr. Am J Roentgenol Radium Ther Nucl Med. 1971 Mar;111(3):501-9
  6. Pickhardt PJ, Fischer KC. Unilateral hypoperfusion or absent perfusion on pulmonary scintigraphy: differential diagnosis.AJR Am J Roentgenol. 1998 Jul;171(1):145-50.
  7. Espinola D, Rupani H, Camargo EE, et al.Ventilation-perfusion imaging in pulmonary papillomatosis. J Nucl Med. 1981 Nov;22(11):975-7
  8. Apau RL, Saenz R, Siemsen JK. Bloodless lung due to bronchial obstruction. J Nucl Med. 1972 Jul;13(7):561-2.
  9. Fazio F, Pratt TA, McKenzie CG, et al. Improvement in regional ventilation and perfusion after radiotherapy for unresectable carcinoma of the bronchus. AJR Am J Roentgenol. 1979 Aug;133(2):191-200.
  10. Slonim SM, Molgaard CP, Khawaja IT, et al. Unilateral absence of right-lung perfusion with normal ventilation on radionuclide lung scan as a sign of aortic dissection. J Nucl Med. 1994 Jun;35(6):1044-7.
  11. Spitzer SA, Segal I, Lubin E, et al. Unilateral increased transradiancy of the lung caused by bronchial carcinoid tumour. Thorax. 1980 Oct;35(10):739-44.
  12. Win T, Tasker AD, Groves AM, et al. Ventilation-perfusion scintigraphy to predict postoperative pulmonary function in lung cancer patients undergoing pneumonectomy. AJR Am J Roentgenol. 2006 Nov;187(5):1260-5.

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